Distinct Effects of Zn, Cu, Fe, and Al on Amyloid-β Stability, Oligomerization, and Aggregation: Amyloid-β Destabilization Promotes Annular Protofibril Formation
نویسندگان
چکیده
Aggregation: Amyloid-β Destabilization Promotes Annular Protofibril Formation Wei-Ting Chen, Yi-Hung Liao, Hui-Ming Yu, Irene H. Cheng, and Yun-Ru Chen From Genomics Research Center, Academia Sinica, Institute of Brain Science, National Yang-Ming University, Taiwan International Graduate Program, Chemical Biology and Molecular Biophysics Program, Genomics Research Center, Academia Sinica, Institute of Biochemical Sciences, National Taiwan University, Taiwan Running head: Distinct metal ion effects on Aβ folding and aggregation *Address correspondence to: Yun-Ru Chen, Genomics Research Center, Academia Sinica, Taiwan. 128, Academia Road, Sec. 2, Nankang Dist., Taipei 115, Taiwan. Tel. 886-2-2787-1275; Fax. 886-2-2789-8771; E-Mail: [email protected]
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